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A cough medicine (or linctus, when in syrup form) is a medicinal drug used in
an attempt to treat coughing and related conditions. For dry coughs,
treatment with cough suppressants (antitussives) may be attempted to suppress
the body's urge to cough. However, in productive coughs (coughs that produce
phlegm), treatment is instead attempted with expectorants (typically
guaifenesin, in most commercial medications) in an attempt to loosen mucus
from the respiratory tract.
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Nimetazepam (marketed under brand name Erimin) is an intermediate-acting
hypnotic drug which is a benzodiazepine derivative. It was first
synthesized by a team at Hoffmann-La Roche in 1962. It possesses hypnotic,
anxiolytic, sedative, and skeletal muscle relaxant properties. Nimetazepam
is also an anticonvulsant. It is sold in 5 mg tablets known as Erimin. It
is generally prescribed for the short-term treatment of severe insomnia in
patients who have difficulty falling asleep or maintaining sleep. Taken
orally, nimetazepam has very good bioavailability with nearly 100% being
absorbed from the gut. It is among the most rapidly absorbed and quickest
acting oral benzodiazepines, and hypnotic effects are typically felt within
15–30 minutes after oral ingestion. The blood level decline of the parent
drug was biphasic with the short half-life ranging from 0. 5-0. 7 hours and
the terminal half-life from 8–26. 5 hours (mean 17. 25 hours). It is the N-
methylated analogue of nitrazepam (Mogadon, Alodorm), to which it is
partially metabolised. Nitrazepam has a long elimination half-life, so
effects of repeated dosage tend to be cumulative.
Methaqualone is a depressant that increases the activity of the GABA
receptors in the brain and nervous system. When GABA activity is increased,
blood pressure drops and the breathing and pulse rates slow, leading to a
state of deep relaxation. These properties explain why methaqualone was
originally mainly prescribed for insomnia.
Methaqualone peaks in the bloodstream within several hours, with a half-
life of 20-60 hours. Regular users build up a physical tolerance, requiring
larger doses for the same effect. Overdose can lead to nervous system
shutdown, coma and death.
Methaqualone is not recommended for use while pregnant and is in pregnancy
category D.